

BI-LAYER MATRIX
The choice for aesthetic and functional results in loss of substances
Skin Expertise with a new collagen technology
NEVELIA® structure
NEVELIA® is a three-dimensional porous matrix of stabilized bovine origin type I Collagen.
NEVELIA® is made of a specific native collagen with a large fibrous proportion to keep cell adhesion signals and mechanical structure to support regeneration.
In vitro tests demonstrate an optimized colonization as fibroblasts recognize collagen fibers.
Additional NEVELIA® features are :
- Optimized pore size3 (average pore size 100 μm) and open-cell structure promoting nutrients flow and fibroblasts migration
- Crosslinking rate for a balanced absorption / regeneration process
- No GAG added to keep cells attachment potential
NEVELIA® is composed of medical-grade silicone elastomer reinforced with a polyester material.

NEVELIA®
Colonization in the matrix thickness, many cells, strong collagen neosynthesis

OTHER BI-LAYER MATRIX
Colonization mainly on the surface, few cells, poor collagen neosynthesis

NEVELIA® MATRIX SEM photography

OTHER BI-LAYER MATRIX SEM photography

NEVELIA®
Reinforced silicone sheeting

OTHER BI-LAYER MATRIX
Non-Reinforced silicone sheeting
NEVELIA® utilizations
NEVELIA® is used for dermal regeneration in skin loss, especially in:
- Burns surgery (third and deep second degree burns and burns sequelae)
- Chronic wounds surgery (including leg ulcers and diabetic foot)
- Traumatology
- Skin tumors surgery
- Reconstructive plastic surgery
NEVELIA® can also be used in children.
NEVELIA® is used in combination with a thin split thickness skin graft to recreate skin close to normal skin in terms of function and appearance.

NEVELIA®, an alternative to
- Skin Expansion (Single or sequential)
- Flaps (Local, distant, free …)
- Split-Thickness or Full-Thickness skin autograft
- Dermal graft (Allografts, Xenografts…)
NEVELIA® Bi-Layer Matrix
clinical benefits for specific indications
Burns surgery
- Waiting donor site availability for extended burns
Chronic wounds surgery
- Good trophicity especially necessary in areas of friction, pressure
- Adapted to prolonged healing time
Traumatology
- Good trophicity especially necessary in areas of friction, pressure
- Adapted to prolonged healing time to combine other treatments
Skin Tumors Surgery
- Wise choice awaiting anatomopathologist results
- Facilitates monitoring of cancer recurrence
- Ease of care for the elderly through faster mobilization
Additional benefits
NEVELIA® Bi-Layer Matrixcan improve treatment in a number of situations.
- Immediate availability
- Efficiency of the surgical technique
- Creation of a thicker protective tissue and reestablishment of the gliding plan in noble elements coverage like muscles, bones, tendons
- Better functional and aesthetic results compared to common dermo-epidermal graft
- No additional scars in traumatology (versus flaps)
- Reduction risk sequelae of donor site
- Does not prevent alternative treatments
- Reduction of hypertrophic scars and keloids occurrence
- Faster procedure which can be performed in ambulatory room for specific indications (hand, skin tumors)
Children : allows better adaptation of tissue to child growth (less tensions & flanges)