NEVELIA®
NEVELIA-LOGO

BI-LAYER MATRIX
The choice for aesthetic and functional results in loss of substances
Skin Expertise with a new collagen technology

NEVELIA® structure

NEVELIA® is a three-dimensional porous matrix of stabilized bovine origin type I Collagen.

NEVELIA® is made of a specific native collagen with a large fibrous proportion to keep cell adhesion signals and mechanical structure to support regeneration.

In vitro tests demonstrate an optimized colonization as fibroblasts recognize collagen fibers.

Additional NEVELIA® features are :

  • Optimized pore size3 (average pore size 100 μm) and open-cell structure promoting nutrients flow and fibroblasts migration
  • Crosslinking rate for a balanced absorption / regeneration process
  • No GAG added to keep cells attachment potential


NEVELIA® is composed of medical-grade silicone elastomer reinforced with a polyester material.

nevelia_structure1

NEVELIA®
Colonization in the matrix thickness, many cells, strong collagen neosynthesis

nevelia_structure2

OTHER BI-LAYER MATRIX  

Colonization mainly on the surface, few cells, poor collagen neosynthesis

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NEVELIA® MATRIX SEM photography

OTHER BI-LAYER MATRIX SEM photography

NEVELIA®-Reinforced-silicone-sheeting

NEVELIA®
Reinforced silicone sheeting

OTHER-BI-LAYER-MATRIX

OTHER BI-LAYER MATRIX 

Non-Reinforced silicone sheeting

NEVELIA® utilizations

NEVELIA® is used for dermal regeneration in skin loss, especially in:

  • Burns surgery (third and deep second degree burns and burns sequelae)
  • Chronic wounds surgery (including leg ulcers and diabetic foot)
  • Traumatology
  • Skin tumors surgery
  • Reconstructive plastic surgery

NEVELIA® can also be used in children.

NEVELIA® is used in combination with a thin split thickness skin graft to recreate skin close to normal skin in terms of function and appearance.

nevelia-burns-chronic-wounds

NEVELIA®, an alternative to

  • Skin Expansion (Single or sequential)
  • Flaps (Local, distant, free …)
  • Split-Thickness or Full-Thickness skin autograft
  • Dermal graft (Allografts, Xenografts…)

NEVELIA® Bi-Layer Matrix

clinical benefits for specific indications

Burns surgery

  • Waiting donor site availability for extended burns

Chronic wounds surgery

  • Good trophicity especially necessary in areas of friction, pressure
  • Adapted to prolonged healing time

Traumatology

  • Good trophicity especially necessary in areas of friction, pressure
  • Adapted to prolonged healing time to combine other treatments

Skin Tumors Surgery

  • Wise choice awaiting anatomopathologist results
  • Facilitates monitoring of cancer recurrence
  • Ease of care for the elderly through faster mobilization

Additional benefits

NEVELIA® Bi-Layer Matrixcan improve treatment in a number of situations.

 

  • Immediate availability
  • Efficiency of the surgical technique
  • Creation of a thicker protective tissue and reestablishment of the gliding plan in noble elements coverage like muscles, bones, tendons
  • Better functional and aesthetic results compared to common dermo-epidermal graft
  • No additional scars in traumatology (versus flaps)
  • Reduction risk sequelae of donor site
  • Does not prevent alternative treatments
  • Reduction of hypertrophic scars and keloids occurrence
  • Faster procedure which can be performed in ambulatory room for specific indications (hand, skin tumors)

 

Children : allows better adaptation of tissue to child growth (less tensions & flanges)